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KMID : 0388420000100010031
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Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.31 ~ p.38
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Tumor Angiogenesis in Squamous Cell Carcinoma of the Uterine Cervix
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Cho Seung-Che
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Abstract
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Tumor growth and metastasis depend on the angiogenic activity. This study was designed to determine the relationship between angiogenesis and prognostic factors of cervical cancer, such as clinical stage, histologic grade, cell type, depth of stromal invasion, presence of lymphovascular invasion and lymph node metastasis The microvessels were identified by immunohistochemistry using antibody to factor ⅤⅢ-related antigen in 60 radical hysterectomy specimens. Three highly vascularized microscopic fields were selected and photographed by digital camera in 200 magnification, and microvessels were counted from photographs. Mean microvessel count is 14.7±5.1. There were no significant differences in microvessel counts and known prognostic factors. Therefore, microvessel count is not good prognostic parameters, according this study.
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KEYWORD
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angiogenesis, uterine cervix, squamous cell carcinoma, prognosis
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